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KMID : 0359720180360020081
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Journal of the Korean Neurological Association
2018 Volume.36 No. 2 p.81 ~ p.85
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The Relationship between Hypertension and the Lesion Distribution of Posterior Reversible Encephalopathy Syndrome
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Lee Moon-Kyu
Song Jae-Seok
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Abstract
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Background: The relationship between hypertension and the lesion distribution of posterior reversible encephalopathy syndrome (PRES) is in debate.
Methods: Twenty patients with PRES which developed during chemotherapy or immunosuppression treatment for the control of underlying malignancy or auto-immune disorders were selected from the database. Data regarding brain images, clinical symptoms, co-morbid illnesses, and mean arterial pressure (MAP) at the pre-symptomatic period (one day before the symptom onset) and at the symptom onset were collected. Patients were divided into two groups according to the presence of pre-symptomatic hypertension. The lesion distribution degree was calculated by numerical method (involvement score [IS]) and compared with MAP.
Results: No significant differences of clinical symptoms were found between two groups. IS and onset period MAP were higher in the hypertensive group. Pre-symptomatic MAP correlated with onset period MAP and IS in total patients. No significant correlation was found between IS and onset period MAP.
Conclusions: The PRES patient with hypertension in the pre-symptomatic period would show more spatially distributed brain lesions than the patient with stable blood pressure.
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KEYWORD
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Posterior reversible encephalopathy syndrome, Hypertension, Brain lesion, Involvement score
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